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AbbVie Senior Scientist I/II, Analytical Characterization, Protein Analytics in Worcester, Massachusetts

Senior Scientist I/II, Analytical Characterization, Protein Analytics

USA, Massachusetts, Worcester

Research & Development

Requisition #1908004

Our Protein Analytics Department located at the AbbVie Bioresearch Center in Worcester, MA is looking for an innovated and driven Senior Scientist I/II to join the Analytical Characterization Team! As a key member of our team, you will support various Abbvie projects and will serve as a lead for antibody, DVD-Ig, ADC and fusion protein therapeutics! Your main responsibility will be to develop a deep understanding of the structure and function relationship, characterization of low level variants, assessment of protein stability and primary structure liabilities, proteomics and analysis of post-translational modifications including glycosylation.

Key Responsibilities Include:

  • Independently develop and apply state of the art mass spectrometry, capillary electrophoresis, and HPLC methods to characterize biotherapeutic proteins and their associated variants and impurities

  • Identify post-translational modifications and characterize structure-activity relationships of products under development

  • Provide technical support and oversight for QC testing occurring at internal and external GMP testing laboratories

  • Plan and author characterization, comparability, and quality sections of regulatory submissions (INDs/CTDs)

  • Develop, qualify/validate, and transfer fit-for-purpose QC release and stability methods

  • Participate in analytical investigations and analytical trouble shooting efforts

  • Serve as an analytical lead for internal AbbVie programs

  • Represent the Protein Analytical Chemistry Group as a subject matter expert on cross functional teams

  • Conducting experiments independently, communicating results at team meetings, authoring reports and contributing to AbbVie filings

Position will be hired based on level of experience.

  • Bachelors, Masters or PhD Degree in Biochemistry, Chemistry, Analytical Chemistry, Biophysics (or related discipline) and 10-12+ (BS), 8-10+ (MS) or 0-4+ (PhD) years of experience in industry or academia

  • Strong background in biophysics and ability to develop enzyme assays; troubleshoot and plot data is preferred

  • Experience with protein mass spectrometry, LC-MS, UPLC, HPLC, capillary electrophoresis, glycoprotein and mAb characterization and bioinformatics

  • Experience with Circular Dichroism (CD), Differential Scanning Calorimetry (DSC), Analytical Ultracentrifugation (AUC), and other biophysical methods is a plus

  • Experience with CMC analytical development of monoclonal antibodies or related biotherapeutic proteins is desired

  • Strong written and verbal communications skills

  • Ability to work in a fast-paced, collaborative environment and leading multiple concurrent projects with a high degree of independence

Key AbbVie Competencies:

  • Builds strong relationships with peers and cross functionally with partners outside of the team to enable higher performance.

  • Learns fast, grasps the “essence” and can change the course quickly where indicated.

  • Raises the bar and is never satisfied with the status quo.

  • Creates a learning environment, open to suggestions and experimentation for improvement.

  • Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Additional Information

  • Travel: No

  • Job Type: Experienced

  • Schedule: Full-time

  • Job Level Code: IC