AbbVie Senior Scientist II, Protein Engineering & Characterization in Worcester, Massachusetts

Senior Scientist II, Protein Engineering & Characterization

USA, Massachusetts, Worcester

Research & Development

Requisition #1802200

We are seeking a highly motivated and creative scientist with a background in protein engineering, expression, purification and analytical characterization to join the AbbVie Global Biologics Discovery organization. This individual will work in drug discovery cross-functional teams both internally and externally to design, produce, characterize and test recombinant proteins for different therapeutic areas including metabolic diseases, oncology, immunology and aging.

Responsibilities:

  • Execute hands on scientific research involving engineering, production and screening of recombinant tool and therapeutic proteins, including antigens, antibodies, fusion proteins and multi-specific biologics.

  • Apply various protein analytical methods to characterize and test recombinant proteins in relevant biochemical and cellular experiments.

  • Work collaboratively with matrixed project teams and members of the Global Biologics Group to drive innovation and deliver novel therapies for patients.

  • Develop productive collaborations and communication with other groups across therapeutic areas.

  • Timely documentation of experiments and activities in electronic archive systems.

  • Engage colleagues in cross-disciplinary scientific discussion, present scientific data to internal and external audiences and publish research in peer-reviewed journals.

Position will be hired based on level of experience:

Qualifications:

  • BS, MS or PhD degree in biochemistry or related discipline with 12+ (BS), 10+ (MS) or 4+ (PhD) years of relevant experience in academic or biotech/pharmaceutical industry setting.

  • Extensive expertise in recombinant protein production, proficiency in analytical techniques for protein characterization (such as mass spectrometry, chromatography and others).

  • Hands-on experience in molecular cloning, and designing/producing novel bi-specific proteins in mammalian and bacterial cells, is highly desired.

  • Proficiency in biochemical assay development including MSD, ForteBio, and receptor ligand interaction assays is desirable.

  • Familiarity with molecular modeling is a plus.

  • Experience in biochemistry and cellular biology of metalloproteinases is a plus.

  • Strong communication and organization skills, especially the ability to work across multiple scientific disciplines and functions.

  • Managerial experience for one or more direct reports is highly desirable.

  • Strong record of performance and scientific accomplishments as demonstrated by impactful contributions to the scientific community, pipeline contributions, peer reviewed publications and patent applications.

Equal Opportunity Employer Minorities/Women/Veterans/Disabled