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AbbVie Senior Scientist, I in Worcester, Massachusetts

Senior Scientist, I

USA, Massachusetts, Worcester

Research & Development

Requisition #2000191

We are seeking a highly-motivated Senior Scientist/Engineer to join our Downstream group in the Manufacturing Sciences department at the AbbVie BioResearch Center based in Worcester, MA. As part of the Manufacturing Sciences organization, our groupleads thedownstream processoptimization, validation, implementation, continuous improvement and global technical support for late-stage and commercial manufacturing of therapeutic proteins and antibody-drug conjugates (ADCs) for AbbVie. We also provide manufacturing support and author regulatory filing CMC sections. The candidate should have experience and comprehensive knowledge in process characterization and process performance qualification. The candidate is expected to devise and implement protein purification and/or ADC strategies to solve complex challenges across the AbbVie pipeline. Excellent written and verbal communication skills are essential.

Key Responsibilities Include:

  • Design, execution, andinterpretation of results of process characterization and optimization experimentalstudies; and the design and documentation of process performancequalification

  • Identify, evaluate, anddevelop innovative technologies within the field of downstream processingto improve process efficiency, robustness and product quality

  • Lead technology and processtransfer activities to pilot scale and GMP plants; solve technical issuesand support GMP manufacturing

  • Participate incross-functional teams and author/review/defend CMC sections of regulatoryfilings

  • Author technical reports,memos and validation documents

  • Interact withcross-functional groups (e.g. Discovery, R&D, Operations, Quality andRegulatory)

  • Author peer-reviewedarticles/patents. Present original work in conferences.

  • BS, MS, or PhD in Chemical orBiochemical Engineering, Biochemistry, or related field with 8+ years(BS), 5-10 years (MS), or 0-5 years (PhD), relevant pharmaceuticalindustry experience

  • Laboratory and/ormanufacturing scale experience with typical protein purification and/or ADC unitoperations (e.g. centrifugation, filtration, chromatography, UF/DF)

  • Development ofADC and/or protein purification unit operations

  • Outstanding record of accomplishment in areas ofpurification bioprocess development, improvement, and validation

  • Strong written and oral communicationskills and the ability to contribute in a multi-disciplinary environmentare essential

  • Interacts well with diverse groups and maintainsstrong working relationships with internal, global, and externalcollaborators

  • Demonstrated problem-solvingskills and capability to overcome complex issues

  • Demonstrated success in coordinating and executingimportant projects to achieve business unit goals.

  • Must have a “results-oriented” work ethic and apositive, “can-do” attitude with a strong sense of urgency andself-motivated desire to achieve.

Preferred Skills:

· Chromatography workstation experience (programming and running), esp. w/ AKTA

· Understanding of antibody-drug conjugation chemistry, knowledge of relevant analytical techniques

Additional Information

  • Significant Work Activities and Conditions: N/A

  • Travel: Yes, 5 % of the Time

  • Job Type: Experienced

  • Schedule: Full-time

  • Job Level Code: IC