AbbVie Senior Scientist, I in Worcester, Massachusetts
Senior Scientist, I
USA, Massachusetts, Worcester
Research & Development
We are seeking a highly-motivated Senior Scientist/Engineer to join our Downstream group in the Manufacturing Sciences department at the AbbVie BioResearch Center based in Worcester, MA. As part of the Manufacturing Sciences organization, our groupleads thedownstream processoptimization, validation, implementation, continuous improvement and global technical support for late-stage and commercial manufacturing of therapeutic proteins and antibody-drug conjugates (ADCs) for AbbVie. We also provide manufacturing support and author regulatory filing CMC sections. The candidate should have experience and comprehensive knowledge in process characterization and process performance qualification. The candidate is expected to devise and implement protein purification and/or ADC strategies to solve complex challenges across the AbbVie pipeline. Excellent written and verbal communication skills are essential.
Key Responsibilities Include:
Design, execution, andinterpretation of results of process characterization and optimization experimentalstudies; and the design and documentation of process performancequalification
Identify, evaluate, anddevelop innovative technologies within the field of downstream processingto improve process efficiency, robustness and product quality
Lead technology and processtransfer activities to pilot scale and GMP plants; solve technical issuesand support GMP manufacturing
Participate incross-functional teams and author/review/defend CMC sections of regulatoryfilings
Author technical reports,memos and validation documents
Interact withcross-functional groups (e.g. Discovery, R&D, Operations, Quality andRegulatory)
Author peer-reviewedarticles/patents. Present original work in conferences.
BS, MS, or PhD in Chemical orBiochemical Engineering, Biochemistry, or related field with 8+ years(BS), 5-10 years (MS), or 0-5 years (PhD), relevant pharmaceuticalindustry experience
Laboratory and/ormanufacturing scale experience with typical protein purification and/or ADC unitoperations (e.g. centrifugation, filtration, chromatography, UF/DF)
Development ofADC and/or protein purification unit operations
Outstanding record of accomplishment in areas ofpurification bioprocess development, improvement, and validation
Strong written and oral communicationskills and the ability to contribute in a multi-disciplinary environmentare essential
Interacts well with diverse groups and maintainsstrong working relationships with internal, global, and externalcollaborators
Demonstrated problem-solvingskills and capability to overcome complex issues
Demonstrated success in coordinating and executingimportant projects to achieve business unit goals.
Must have a “results-oriented” work ethic and apositive, “can-do” attitude with a strong sense of urgency andself-motivated desire to achieve.
· Chromatography workstation experience (programming and running), esp. w/ AKTA
· Understanding of antibody-drug conjugation chemistry, knowledge of relevant analytical techniques
Significant Work Activities and Conditions: N/A
Travel: Yes, 5 % of the Time
Job Type: Experienced
Job Level Code: IC