AbbVie Senior Scientist I, Global Biologics Discovery in Worcester, Massachusetts
Senior Scientist I, Global Biologics Discovery
USA, Massachusetts, Worcester
1 additional location
Research & Development
We are seeking a highly motivated and creative scientist to join the AbbVie Global Biologics Discovery organization. This individual will contribute to the development and testing of novel fusion proteins and to the exploration of protease activation/localization in normal vs. diseased tissues. Expertise in protease and extracellular matrix biology in mammalian systems preferred, as well as scientific knowledge of one or more of the following: Immunology, Oncology and Immuno-Oncology therapeutic areas. This individual willwork in drug discovery cross-functional teams both internally and externally.
Execute hands on scientific researchinvolving screening of recombinant tool and therapeutic proteins, includingantigens, antibodies, fusion proteins and multi-specific biologics.
Apply various in vitro analytical methods to characterize and test recombinantproteins in relevant biochemical and cellular experiments.
Work collaboratively with matrixedproject teams and members of the Global Biologics Group to drive innovation anddeliver novel therapies for patients.
Develop productive collaborations and communicationwith other groups across therapeutic areas.
Timely documentation of experiments and activities in electronicarchive systems.
Engagecolleagues in cross-disciplinary scientific discussion, present scientific datato internal and external audiences and publish research in peer-reviewedjournals.
Position will be hired based on level of experience.
BS, MS or PhD degree in biological sciences with 10+ (BS), 8+ (MS) or 0+ (PhD) years of relevantexperience in academic or biotech/pharmaceutical industry setting or equivalent
Extensive expertise in mammalian cellculture/transfection and in vitro analyticaltechniques for protein characterization (such as ELISA, western blot, FACs& cell-based activity assays) necessary.
Hands-on experience in ex vivo tissue fractionation (to isolateextracellular matrix, cell membranes and cytosol) and cell fractionation(organelle isolation) preferred.
Experience in biochemistry and cellularbiology of proteases is preferred.
Experience with in vivo rodent models(xenograft, CIA and IBD) a plus.
Experience in protein engineering,CRISPR a plus.
Strong communication and organization skills, especially the abilityto work across multiple scientific disciplines and functions.
Strong record of performance and scientific accomplishments asdemonstrated by impactful contributions to the scientific community, pipelinecontributions, peer reviewed publications and patent applications.
Job Type: Experienced