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AbbVie Senior Scientist II, Bioinformatics in Sunnyvale, California

Senior Scientist II, Bioinformatics

USA, California, Sunnyvale

Research & Development

Requisition #2001392

General Position Summary/Purpose:

  • Contribute to multiple stages of development of targeted therapies by supporting the implementation of scientifically driven development plans, primarily on setting up the strategy and executing on bioinformatics analysis of novel target discovery and biomarkers of interest for various projects.

  • Practical knowledge and leadership experiences in experimental designs for preclinical and early clinical drug discovery projects.

  • Develop, maintain, and refine bioinformatics workflows and analytical tools for preclinical and clinical biomarker data analysis. Current focus of this position is primarily on preclinical discovery biological research.

  • Practical knowledge of bioinformatics tools and resources, experience with next generation sequencing (NGS) data,various high-throughput omics analysis pipeline development, integrative omics data and cloud computing,and strong background in genomics and molecular biology.

  • As a member of our bioinformatics group working with other research scientists in a highly collaborative and dynamic environment to support biomarker investigations and translational medicine. Key Accountabilities/Core Job Responsibilities:

  • Providing appropriate experimental design and biospecimen sampling scheme, molecular data analysis strategy and statistical support to identify mechanisms of action or resistance for oncology therapeutics, identification of novel targets and candidate biomarkers for various programs and projects and other research objectives.

  • Working with standard bioinformatics tools, visualization packages, and omics databases/annotations resources.

  • Developing and using bioinformatics pipelines to prepare and analyze data, working closely with data engineers in pipeline developments.

  • Analyzing and working with NGS data, ideally whole genome and exome sequence data and other omics data etc.

  • Interpreting and translating data to biological knowledge.

Presentation in internal group meetings or external scientific meetings


  • Expertise and experiences in experimental designs.

  • Demonstrated fluency in UNIX/Linux computing environment (3+ years)

  • Proficiency in R programming (3+ years), other programming skills such as in C/C++ and a scripting language such as Perl or Python would be desirable.

  • Familiarity with SAS, JMP or JMP Genomics, OmicSoft ArraySuite are a plus.

  • Excellent working knowledge of current best practices in genetic variant discovery and validation methods.

  • Strong organizational, written, and communication skills.

  • Excellent analytical and problem-solving abilities.

  • A proven track record in scientific publications and invited presentations at major conferences on target discovery and biomarkers.

  • Knowledge of cellular and molecular biology, oncology, and drug development processes.

  • Enjoys working in a fast paced and highly collaborative dynamic environment with a diverse team to tackle complex problems.

  • Eager to learn and think outside the box.

  • Is disciplined and driven to deliver ongoing research results.

  • Has a positive attitude with a willingness to roll up their sleeves and do what it takes to get the job done.

  • Is highly organized and detail oriented.

  • Is a strong written and verbal communicator.

  • Has a hard work ethic with emphasis on execution.

Education Requirements (degree, certifications, etc.): Include must have and preferred

For the Senior Scientist I level, we require:

  • Bachelor’s Degree or equivalent education and typically10years of experience, Master’s Degree or equivalent education and typically8years of experience,PhD and no experience necessary.

  • Strong molecular biology background, and industry experience preferred

For the Senior Scientist II level, we require:

  • Bachelor’s Degree or equivalent education and typically12years of experience, Master’s Degree or equivalent education and typically10years of experience, PhD and typically4years of experience.

  • Strong molecular biology background, and industry experience preferred

Preferred Skills/Abilities

  • Experiences in developing therapeutics for oncology or immunology or immune-oncology

  • Strong understanding and proven track record in genomics/genetics technology and applications to clinical development.

Additional Information

  • Significant Work Activities and Conditions: N/A

  • Travel: No

  • Job Type: Experienced

  • Schedule: Full-time

  • Job Level Code: M