AbbVie Scientist I/II, In Vivo Pharmacology in South San Francisco, California
Scientist I/II, In Vivo Pharmacology
USA, California, South San Francisco
Research & Development
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica, Venclexta, and Empliciti — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.
AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, statisticians, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position will be based at AbbVie’s South San Francisco oncology site.
We are looking for a Scientist I/II with experience in in vivo pharmacology and optical imaging study execution, start to finish including tumor implantation, tumor measurement and/or imaging data collection, and data analyses. The candidate will participate in, with opportunities for leading, bioluminescent, fluorescent, photoacoustic, and/or ultrasound in vivo imaging research and projects. Additional opportunities to learn new skills and to work on ex vivo lab experiments will be provided depending on the project and candidate’s interests. The ideal candidate will be highly motivated, collaborative with multi-disciplinary teams, and have extensive in vivo skills in the field of oncology.
KEY RESPONSIBILITIES INCLUDE:
Execute in vivo studies involving CDX, PDX, orthotopic models, syngeneic models, etc. for various cancer subtypes.
Perform all aspects of in vivo experimentation including cell inoculation, tumor/weight measurement data recording, randomization, dosing, sample collection (50-70% of work week).
Evaluate novel cancer therapeutics in vivo through studies such as efficacy, PK, tolerability, and support new mouse model development research.Execute in vivo imaging studies supporting research and therapeutic evaluation in vitro cell culture of CDX models to support initiation of in vivo studies analyze and report data regularly at team meetings.
For the Scientist I, we require:
- Bachelor’s Degree or equivalent education with typically 5 years of experience, or Master’s Degree or equivalent education with typically two years of experience.
For the Scientist II, we require:
- BS or equivalent education with typically 7 or more years of experience or MS or equivalent education with typically 5 or more years of experience.
For both levels, we require:
Strong technical expertise in in vivo experimentation, including health monitoring, tumor implantation, tumor measurements, dosing via IP, IV, SC, PO routes, and blood/tissue collection.
Experience with mouse models of cancer, including CDX (cell line derived) and/or PDX (Patient Derived Xenograft) models preferred.
In vivo imaging experience with optical imaging (bioluminescence/fluorescence) is desired, but not required.
Excellent laboratory, record keeping, data analysis, and critical thinking skills
Willing to have schedule flexibility.
A team player with excellent verbal and written communication skills.
Strong organizational skills, attention to detail, and time-management skills enabling efficiency and independence.
Significant Work Activities and Conditions: N/A
Travel: Yes, 5 % of the Time
Job Type: Experienced
Job Level Code: IC