AbbVie Scientist II / Sr. Scientist I, Cell Culture Development (Process Sciences) in South San Francisco, California
Scientist II / Sr. Scientist I, Cell Culture Development (Process Sciences)
USA, California, South San Francisco
Research & Development
Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica®, Venclexta™, and Empliciti™ — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.
AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position will be based at Stemcentrx, AbbVie's South San Francisco, CA location.
Abbvie Stemcentrx is embracing new paradigms and technologies to discover and develop novel oncology therapies. We are seeking a highly-motivated Scientist to join the Cell Culture Development group in Process Sciences, a talented and multi-disciplinary team advancing an exciting pipeline of novel therapeutic drug candidates, including antibody-drug conjugates (ADCs). The successful applicant will assume a number of responsibilities related to the development, scale-up, and technology transfer of cell culture production processes for programs in the preclinical and clinical pipeline and will have a unique opportunity to contribute to all aspects of the development of stable production cell lines. This position requires close collaboration with Cell Line Development teammates as well as downstream Process and Analytical Development groups, Manufacturing, Quality, and Regulatory Affairs.
Key Responsibilities include:
Rapidly develop CHO cell culture processes, including clone selection, media optimization, and bioreactor process parameter optimization
Execute bench-scale and pilot-scale production of antibodies to supply material for GLP toxicology studies and for use by other development groups
Coordinate scale-up and technology transfer activities to support early and late-stage GMP manufacturing batches
Author, review, and provide continual improvement to Batch Records/SOPs and provide on-floor GMP production support
Provide technical documentation in support of filings with Regulatory agencies
Mentor associate scientists
BS/MS in Biochemical/Chemical Engineering or related discipline with at least 5-10 years of relevant experience or PhD with 1-3 years of relevant experience in the biotechnology/biopharmaceutical industry
Technical expertise in small-scale and large-scale bioreactor control systems for mammalian cell culture and complex problem-solving of science/engineering challenges
Experience with single-use technologies and automation for high-throughput process development, particularly the ambr250 system
Knowledge of process optimization methods such as Design of Experiments (DOE)
Knowledge of cGMP requirements and regulatory agency guidelines for stable production cell lines
Mandatory professional skills include:
Organized and disciplined record keeping in electronic lab notebooks
Excellent communication, technical writing skills, and presentation skills
Ability to work effectively with others in a dynamic environment with an positive, hard-working, and team-oriented attitude
Ability to self-motivate, multi-task, meet frequently tight deadlines, and provide mentorship