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AbbVie Senior Scientist, Biochemistry - Targeted Protein Degradation in North Chicago, Illinois

Senior Scientist, Biochemistry - Targeted Protein Degradation

USA, Illinois, Lake County

Research & Development

Requisition #1906196

We are seeking a highly-motivated biochemist, preferably with pharma/biotech experience, to join the Protein Degradation group in North Chicago, IL. This individual should have expertise in ubiquitin-related signaling or targeted protein degradation biology. A proven track record in successfully developing biochemical assays that probe this system is preferred. This individual should enjoy working with innovative technologies in a fast-paced environment.

Key responsibilities

  • Providing expertise in ubiquitin-related signaling and E3 ligase biology

  • Develop innovative strategies to study Protein Degrader engagement with the ubiquitin proteasome system

  • Developed robust in vitro profiling assays that support chemistry efforts in understanding structure-activity relationships

  • Apply novel techniques towards Protein Degrader drug discovery and elucidation of mechanism of action

  • Lead and interact with cross-functional scientific teams

  • Read and apply relevant scientific literature

  • Present research activities at internal and external meetings.


  • BS, MS, or PhD with 10+ (BS), 8+(MS), or 0+(PhD) in biochemistry, enzymology, chemical biology or related fields

  • Experience and publication track record in ubiquitin-proteasome system and/or targeted protein degradation biology

  • Proficient at developing enzyme activity assays and/or protein-protein interaction assays

  • Experience with molecular and cell biology techniques.

  • Experience analyzing data using statistical software programs such as GraphPad PRISM, Microsoft Excel, and Spotfire

  • Motivated, independent, and productive problem solver with a proven ability to advance new scientific understandings

  • Excellent verbal and non-verbal communication skills

  • Ability to work independently, yet works efficiently in teams to achieve objectives

  • Present research activities/results at internal and external meetings, and publish in peer-reviewed journals

Additional Information

  • Significant Work Activities and Conditions: Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)

  • Travel: No

  • Job Type: Experienced

  • Schedule: Full-time

  • Job Level Code: M