AbbVie Senior Scientist I - Preclinical Imaging Ligand Biologist, Neuroscience Discovery in Ludwigshafen, Germany

Senior Scientist I - Preclinical Imaging Ligand Biologist, Neuroscience Discovery

Germany, Rhinland-Palatinate, Ludwigshafen

Research & Development

Requisition #1805452

This position is an excellent opportunity for a scientist interested to work in the field of imaging ligand development in preclinical Discovery applying state-of-the-art technologies in the context of cutting-edge science. Interest and basic knowledge in neurodegenerative diseases like Alzheimer´s Disease, AD, Parkinson´s Disease, PD and multiple sclerosis, MS is expected.

  • Joining a team in the group of Molecular and Imaging Biomarkers, in a laboratory with an established track record applying radioligand binding for the development of PET imaging ligands. Technologies applied at present are radioligand binding and autoradiography.

  • Expected to make substantial contributions to the discovery, characterization and validation of new Positron Emission Tomography (PET) radiotracers for brain imaging, using established and novel methodologies.

  • Independently design and execute high quality radioligand binding experiments on cell membranes and post mortem brain tissue preparations

  • Independently design, execute and analyze radioligand binding experiments on post mortem rodent and human brain sections, to demonstrate target engagement and/or determine the distribution of the target in the brain (autoradiography)

  • Independently conceive and implement new technological approaches to ask specific scientific questions (for example, emulsion autoradiography to demonstrate target engagement)

  • Coordination, implementation, data analysis and reporting of the experiments, including presentations to the relevant team meetings

  • Biology expert in radioligand technologies within Neuroscience Discovery. Interfaces mainly with colleagues in other disciplines like chemistry, biology, neuroanatomy and in vivo imaging.

  • Consulting with pharmacology for the use of radiotracers in preclinical applications to support the translational strategy of novel therapeutics in the field of neurodegenerative diseases.

  • Opportunity to contribute to developing scientific strategies collaboratively across AbbVie Neuroscience towards development and application of new technologies for the development of imaging ligands, e.g. non-radioactive techniques to replace radioactive technologies.

  • Implement publication record in international peer-reviewed journals.

  • Ph.D. (no experience necessary) or Master’s Degree or equivalent education and 8 years of experience, in the field of radioligand binding, ideally applied in the context of neurosciences.

  • Strong background in application of radioligand binding techniques in vitro / ex vivo and analyses of datasets.

  • Understanding of human and rodent neuroanatomy that underlie current best practices in the field are desirable attributes.

  • Previous experience in animal handling and potentially drug treatment in rodents or immunohistochemistry (IHC) or biochemistry are a plus.

  • Ability to work independently and demonstration of experience in the design of experiments and project approaches as well as result interpretation and presentation.

  • Highly motivated, self-driven and results-oriented person with excellent communication and presentation skills, capable to work both as team player and driver for results. High degree of flexibility in adapting to different projects and persons. Excellent networking and relationship-building skills are required.

  • A keen interest in the relevant concepts in biology of neurodegenerative diseases, e.g. AD, PD, MS and for the application of translational biomarker in these fields. Domain expertise in biomarker application and knowledge of translational approaches is a plus.

  • Passion for solving technical problems and applying new technologies to further scientific goals.

  • Fluency in English and knowledge of German.

We are looking forward to your application. Please provide information about your salary expectations and possible start date in your motivation letter.

An equal opportunity employer. AbbVie welcomes and encourages diversity in our workforce.

Learn more about AbbVie Deutschland at www.abbvie.de . Visit www.abbvie-care.de for more information about the therapeutic areas in which we’re active.