AbbVie Senior/Principal Scientist, Biotransformation, DMPK-BA in Lake County, Illinois
Senior/Principal Scientist, Biotransformation, DMPK-BA
USA, Illinois, Lake County
1 additional location
Research & Development
The Biotransformation group in DMPK-BA has an open position for a Senior/Principal Scientist to lead drug metabolism studies to support drug discovery and development. The selected candidate will be responsible for designing and conducting ADME investigations, interpret results, and apply knowledge to drive the pipeline and answer key scientific questions. The candidate will collaborate across various disciplines within AbbVie including DMPK, chemistry, biology, toxicology, pathology, clinical and regulatory to support biotransformation.
The individual is expected to have a high level of practical experience performing in vivo and in vitro biotransformation studies, analytical method development, metabolite profiling, handling radioactive compounds, technology development and possess strong written and oral communication skills.
Duties will be focused on laboratory work but could be expanded to broader duties based upon interest, ability, and project needs
Key Responsibilities Include:
Design, perform, interpret, and report appropriate data from in vivo and in vitro studies for identifying metabolite structures and associated pathways
DMPK subject matter expert and provides clear data interpretation and strategy to DMPK colleagues, project teams and management
Routinely operate LC-MS/MS instrumentation, including maintenance and troubleshooting.
Writing or contributing to study reports and regulatory submissions.
Keeps well-informed of literature; Evaluate new methods, technologies, study designs and equipment.
Utilizes expertise to direct projects and is visible outside of functional area
Candidate will accept supervision of associate scientists- people management is required
Provide training, development and guidance to staff.
Level will be based on education and years of experience
Motivated Ph.D. in life sciences with 5-10 years, MS with 7-12 years relevant academic or industry research experience in small molecule development.
Expert in drug metabolism processes, including method development, metabolite profiling, metabolic processes, Mass Spectrometry and related techniques
Previous DMPK experience driving candidates from drug discovery through development
Experience writing regulatory documentation is preferred
Understanding of drug metabolizing enzymes, transporters, and pharmacokinetic principles is preferred.
Understanding the utility of modeling as a prediction tool is preferred.
Advanced training with radio-active material is preferred
Strong interpersonal skills, the ability to work independently with minimal supervision in managing multiple projects and priorities and work well within a team
Strong presentation and written/verbal communication skills.
Key Leadership Competencies:
Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance
Learns fast, grasps the 'essence' and can change the course quickly where indicated
Raises the bar and is never satisfied with the status quo
Creates a learning environment, open to suggestions and experimentation for improvement
Embraces the ideas of others, nurtures innovation and manages innovation to reality
AbbVie is an Equal Employment Opportunity employer: At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer, gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic., we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information
Significant Work Activities and Conditions: N/A
Job Type: Experienced