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AbbVie Associate Scientist I/II, Biotransformation DMPK in Lake County, Illinois

Associate Scientist I/II, Biotransformation DMPK

USA, Illinois, Lake County

1 additional location

USA, Illinois

Research & Development

Requisition #1902693

Associate Scientist I/II, Biotransformation

The candidate for this Associate Scientist I/II position will be working in the Biotransformation group of AbbVie’s Bioanalysis and Biotransformation department. This position will be focused on preparing biological samples and performing LCMS assays to characterize biotransformation of large molecules, including antibodies, antibody-drug conjugates, and proteins. The individual will be expected to have solid experience working with analytical instruments, especially HPLC and MS, and preferred to have experience working with protein samples and protein chemistry techniques.

This individual must independently generate accurate, reliable and reproducible data in a timely manner and demonstrate strong data interpretation skills. The individual must be highly motivated and possess a fundamental understanding of analytical chemistry with the ability to quickly learn and apply various analytical techniques such as chromatography, spectroscopy and wet chemical techniques.

BS in Chemistry with 1-4 years of lab experience required or Masters Degree and no additional experience required. Solid use of instruments including HPLC, MS, UV/VIS, and NMR. Solid documentation skills and ability to present findings to larger groups are valuable. Familiarity of GMP, GLP beneficial but not required.

Required skills include sample preparation in an analytical chemistry setting and analysis of LCMS data and reporting of results. Other beneficial qualities include experience in protein chemistry, proteomics, safety protocols regarding controlled drug and radioactive compounds, or working with Thermo Orbitrap or Agilent QTOF mass spectrometers. The candidate will be expected to coordinate among a group to manage shared resources, but the majority of the work will be on an individual basis.

Responsibilities:

  • Performing biological incubations of drug molecules, purification of biological samples, optimization of LCMS methods, and analysis of LCMS data.

  • Planning and perform routine tasks competently and independently within a timely fashion, and generate reliable and consistent results.

  • Documentation of experimental activities and results using an electronic data acquisition and management systems.

  • Analyze and critique results, noting significant deviations from the expected results.

  • Troubleshoot experiments and instrumentation.

  • Learn and understand new experimental techniques with a curiosity to apply them for unique project / assignment requirements.

  • Demonstrate skill in multiple techniques and appropriately modify protocols, as required, to suit the changing needs of research or development sciences.

  • Place data in proper scientific context by consulting and citing relevant literature.

  • Demonstrate technical proficiency in his/her field, preferentially in the analytical areas of quantitative and instrumental analysis.

  • Impact projects predominantly through lab and/or pilot plant based activities.

  • Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug and radioactive compounds, GxP compliance, and animal care where applicable.

Key Leadership Competencies:

  • Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.

  • Learns fast, grasps the "essence" and can change course quickly where indicated.

  • Raises the bar and is never satisfied with the status quo.

  • Creates a learning environment, open to suggestions and experimentation for improvement.

  • Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Level will be based on education and years of experience

Basic:

  • Bachelor’s Degree, or equivalent education, with typically 1-4 or more years’ experience or Master’s Degree or equivalent education (no additional experience but must be in a a relevant field).

  • Theoretical and practical knowledge to carry out job function.

Additional Information

  • AbbVie is an Equal Employment Opportunity employer: At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer, we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.

  • Significant Work Activities and Conditions: N/A

  • Travel: No

  • Job Type: Experienced

  • Schedule: Full-time

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