AbbVie Associate Scientist, Neuroscience, Alzheimer’s Disease in Cambridge, Massachusetts

Associate Scientist, Neuroscience, Alzheimer’s Disease

USA, Massachusetts, Cambridge

Research & Development

Requisition #1805352

AbbVie has established the Foundational Neuroscience Center (FNC) in Cambridge, MA to investigate the fundamental biological mechanisms and to develop therapeutic interventions for neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases.

The Tau Biology group is seeking a highly motivated applicant with prior experience and expertise in target validation and assay development in neuroscience. The Scientist will support a project leader in 1) CRISPR / Cas9 screening, 2) perform multiplexed image-based screening studies of small molecules and inhibitors of tau aggregation in neurons.

Key ResponsibilitiesInclude:

  • Analyze human AD brain tissues and extract protein of interestusing western blot, MSD, and other biochemical assays

  • Culture hiPSC (human-induced pluripotent stem cell) neurons androdent primary neurons

  • Design and perform tau aggregation inhibition studies inneuronal cultures using high-content, high-throughput robotic-assisted imaging,multiplexed imaging, and confocal microscopy.Analyze and present the results to validate novel drug targets.

  • Work diligently and efficiently to meet deadlines in a fast-pacedenvironment.

  • Read and apply relevant scientific literature.


  • B.S or MS degree in System Neuroscience or related field with0-3+ (BS) or 0+ (MS) years of experience. Industry experience preferred.

  • Proficiency withstandard cell biology, biochemistry, and microscopy methods.

  • Expertise in developing biochemical and cellular assays for highthroughput screening.

  • Familiarity with plate readers and/or high content imaging /familiarity with neuroanatomy is plus but not required.

  • Comfortable using computer programs such as Microsoft, GoogleDocs, Microsoft Excel, etc.

  • Highly motivated, detailed oriented, curious of the science, anddesire to learn to novel neuroscience techniques.

  • Demonstrate critical thinking, independence, clear scientificwriting & verbal communication skills and precise record keeping

  • Strong organizational skills that facilitate planning,multitasking and working within timelines.

Equal Opportunity Employer Minorities/Women/Veterans/Disabled