AbbVie Principal Research Scientist in Cambridge, Massachusetts

AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott Laboratories. AbbVie employs more than 28,000 people worldwide and markets medicines in more than 170 countries. The AbbVie Foundational Neuroscience Center (FNC) is a new facility dedicated to the discovery of new treatment for Alzheimer’s disease.

Key Responsibilities Include:

The aggregation and propagation of the microtubule associated protein tau are key events in the pathophysiology of Alzheimer’s disease. The goal of the tau pathobiology group is to uncover biological mechanisms that underpin this fundamental pathological process and identify new treatments to prevent and/or slow down the neurodegeneration associated with Alzheimer’s disease.

The tau pathobiology group has an opening for a Principal Scientist to support our current effort. The successful candidate will focus on the imbalance of tau proteostasis causing the accumulation and aggregation of tau in Alzheimer’s disease.The Principal Scientist will be responsible for developing assays for proteasome function and investigate its role in the accumulation of tau. As target concepts are validated, the principal scientist will lead drug discovery efforts to advance compounds to the clinic.

  • As part of the global Tau Pathobiology group, set and execute Abbvie’s Tau pathobiology strategy
  • Contribute scientific and technical expertise to multiple project teams focused on Tau aggregation and propagation.
  • Generate robust and complete data sets to make key Go/NoGo decisions on novel drug targets
  • Work with multi-disciplinary teams of scientists across AbbVie
  • Work diligently and efficiently to meet deadlines in a fast-paced environment
  • Maintain a healthy, safe, and inclusive work environment
    • *

Basic: * PhD in neuroscience/cell biology or closely related field with 8-10 years of postdoc experience including a minimum of 5 years in an industrial drug discovery environment. * Experience in neurodegeneration research, with a special consideration for Alzheimer’s disease. * Specific expertise in protein homeostasis pathway, biochemistry or enzymology with a thorough understanding of the protein quality control mechanisms * Proficiency in standard cell and molecular biology, biochemistry and neuroscience techniques including iPSC-derived neuron culture, gene transfer methods, microscopy, protein detection & quantification, and enzyme kinetic assays * Strong record of scientific accomplishment as demonstrated by a publication record in high-impact journals * Strong interpersonal skills with an ability to work productively and creatively in a multi-disciplinary environment * Strong organizational skills that enable multitasking and working within timelines

Job Classification: Experienced
Primary Location: USA-Massachusetts-Cambridge
Organization: Research & Development
Schedule: Full-time
Shift: Day
Travel: Yes, 5 % of the Time
Req ID: 1705351

Equal Opportunity Employer Minorities/Women/Veterans/Disabled